I am not sure if this is something to do with Mac, thunderbolt or even your Quantum.
I have something similar on my Win10 with audiobox 96, after latest Universal Control update. My audiobox isn't recognised by Universal Control app. It does playback sound and my device manager still sees the audiobox. It just happens that the Universal Control launcher does not recognise it. The UC icon in my taskbar also turned darkblue instead of bright blue, like if it isn't active. If I open the launcher, I now get this. I am not sure if this is correct. Also I fail to find any update logs what the update actually does. But tried same things as you. Maybe you see the same in your launcher on Mac? Normally I see sample rate and block size settings here.